TY - CHAP M1 - Book, Section TI - Thrombocytopenia A1 - Diz-Küçükkaya, Reyhan A1 - López, José A. A2 - Kaushansky, Kenneth A2 - Levi, Marcel Y1 - 2017 N1 - T2 - Williams Hematology Hemostasis and Thrombosis AB - SUMMARYThrombocytopenia is one of the most frequent causes for hematologic consultation in the practice of medicine and may be life threatening. Although the normal platelet count in humans (150 to 400 × 109/L) far exceeds the minimal level required to avoid pathologic hemorrhage (<50 × 109/L), a number of medical conditions either increasing the destruction of platelets or reducing their production enhance the risk of bleeding. This chapter discusses an approach to the diagnosis of thrombocytopenia, grouping various causes by mechanism of action, and describing our current understanding of the pathogenesis, treatment, and prognosis. In the vast majority of patients, a cause for thrombocytopenia can be identified and effective therapy instituted. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/06 UR - hemonc.mhmedical.com/content.aspx?aid=1148371772 ER -