TY - CHAP M1 - Book, Section TI - Heparin-Induced Thrombocytopenia A1 - Cuker, Adam A1 - Poncz, Mortimer A2 - Kaushansky, Kenneth A2 - Levi, Marcel Y1 - 2017 N1 - T2 - Williams Hematology Hemostasis and Thrombosis AB - SUMMARYHeparin-induced thrombocytopenia (HIT) is a prothrombotic complication of treatment with heparin. It is associated with mild-to-moderate thrombocytopenia, although the main clinical concern is the high frequency of both arterial and venous thromboembolism, which may be limb- or life-threatening. HIT is an immune complex–based disorder involving platelet factor 4 complexed to negatively charged multimeric molecules, especially surface heparan side chains. It is initiated by exposure to heparin, particularly unfractionated heparin. There is growing understanding of the unusual nature of the underlying immune response in HIT, why certain individuals develop this disorder, and why HIT is prothrombotic. Diagnosis is based on an assessment of clinical probability and specialized laboratory testing. Management involves immediate cessation of heparin and initiation of inhibitors of thrombin or factor Xa. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/08 UR - hemonc.mhmedical.com/content.aspx?aid=1148371856 ER -