TY - CHAP M1 - Book, Section TI - The Biology of Innate Lymphoid Cells and Natural Killer Cells A1 - Trinchieri, Giorgio A1 - Childs, Richard W. A1 - Lanier, Lewis L. A2 - Kaushansky, Kenneth A2 - Prchal, Josef T. A2 - Burns, Linda J. A2 - Lichtman, Marshall A. A2 - Levi, Marcel A2 - Linch, David C. Y1 - 2021 N1 - T2 - Williams Hematology, 10e AB - SUMMARYInnate lymphoid cells (ILCs) are a distinct lineage of lymphocytes that differ from immune lymphoid cells by not expressing somatically rearranged genes encoding antigen specific receptors. They are important in maintaining the homeostasis of different tissues and they have been classified into group 1, 2, and 3 based on their homology in functions and cytokine production with the T-helper subsets Th1, Th2, and Th22/17, respectively. Natural killer (NK) cells are now considered to belong to group 1 ILCS. NK cells have a constitutive ability to mediate cytotoxicity of pathologic target cells and to secrete cytokines, participate in the innate resistance to intracellular pathogens and malignancies, and have a modulatory effect on adaptive immunity and hematopoiesis. NK cell activity is regulated by the opposite effects of activating and inhibitory receptors. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - hemonc.mhmedical.com/content.aspx?aid=1178737619 ER -