TY - CHAP M1 - Book, Section TI - The Vascular Purpuras A1 - Alexandrescu, Doru T. A1 - Levi, Marcel A2 - Kaushansky, Kenneth A2 - Prchal, Josef T. A2 - Burns, Linda J. A2 - Lichtman, Marshall A. A2 - Levi, Marcel A2 - Linch, David C. Y1 - 2021 N1 - T2 - Williams Hematology, 10e AB - SUMMARYPurpura, the clinical manifestation of blood extravasation into mucosa or skin, results from various conditions, including rheumatologic, infectious, dermatologic, traumatic, and hematologic disorders. This chapter does not detail purpura resulting from quantitative or functional defects in hemostasis and coagulation, such as deficiencies of platelets or coagulation factors; these causes are discussed in other chapters (eg, thrombocytopenia in Chap. 116, coagulation factor deficiencies in Chaps. 122 and 123).The differential diagnosis of the disparate causes of noncoagulopathic purpura is best approached by stratifying purpura into three types of lesions: (1) palpable or retiform and noninflammatory, such as hyperglobulinemic purpura of Waldenström; (2) palpable or nonpalpable but inflammatory, such as Henoch-Schönlein purpura; and (3) nonpalpable and noninflammatory, such as senile purpura. By accounting for palpability, presence of inflammation, size, and shape, the differential diagnosis of a particular lesion can be significantly reduced. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/08 UR - hemonc.mhmedical.com/content.aspx?aid=1178754889 ER -