TY - CHAP M1 - Book, Section TI - Preface A1 - Harrington, Lea A. A1 - Tannock, Ian F. A1 - Hill, Richard P. A1 - Cescon, David W. Y1 - 2021 N1 - T2 - The Basic Science of Oncology, 6e AB - Since the publication of the fifth edition of The Basic Science of Oncology our knowledge about the molecular basis of cancer has continued to grow, as a result of the continued rapid development of powerful techniques to study the genome and epigenome, as well as the levels of gene expression and the proteins that are produced. Concurrent with understanding of the molecular pathways that drive the development and progression of cancer, and the heterogeneity of the changes in these pathways in individual cancers, new molecular-targeted agents have been developed and are being tested, with variable success, in attempts to treat cancers selectively. The sixth edition of The Basic Science of Oncology places these major advances in the context of previous studies that have generated the important background to cancer biology. Many of the chapters have new authors and have been extensively revised and rewritten to reflect our new knowledge. We have added new chapters on Epigenetics (Chapter 3) and Molecular Targeted Therapies (Chapter 19). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1179322846 ER -