TY - CHAP M1 - Book, Section TI - Ischemia-Reperfusion Pathobiology in Sickle Cell Anemia A1 - Hebbel, Robert P. A1 - Belcher, John D. A1 - Vercellotti, Gregory M. A2 - Gladwin, Mark T. A2 - Kato, Gregory J. A2 - Novelli, Enrico M. Y1 - 2021 N1 - T2 - Sickle Cell Disease AB - The polymerization of deoxygenated sickle hemoglobin provides the elemental basis for the pathophysiology of sickle cell anemia (SCA). Nonetheless, this disease still presents abundant uncertainties and mysteries, something particularly true for events involved in the occurrence, resolution, and consequences of sickle vaso-occlusion.1 This chapter will describe the unique character of ischemia-reperfusion (I/R) pathophysiology occurring in SCA and why it likely plays a pivotal role in its pathophysiology. Indeed, some features of SCA are less easily explained, in particular the perpetuity, intensity, systematicity, complexity, and instability of its unique inflammatory state.2-4 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1179338362 ER -