TY  - CHAP
M1  - Book, Section
TI  - Mechanistic Insights on Sickle Cell Pathophysiology Learned From Transgenic Mouse Models
A1  - Gupta, Kalpna
A1  - Hsu, Lewis L.
A2  - Gladwin, Mark T.
A2  - Kato, Gregory J.
A2  - Novelli, Enrico M.
Y1  - 2021
N1  - 
T2  - Sickle Cell Disease
AB  - This  chapter  will  introduce  how  mouse  models  have  provided  insights  on  the  pathobiology  and  comorbidities  of  sickle  cell  disease  (SCD),  including  vaso-occlusion  and  pain,  which  are  the  clinical  hallmarks  of  SCD.  Types  of  transgenic  sickle  mouse  models  will  be  presented,  highlighting  the  correlation  between  hemoglobin  pattern,  anemia,  and  acute  microcirculatory  obstruction.  Translational  research  using  sickle  mice  has  provided  insights  into  the  mechanisms  underlying  acute  and  chronic  pain  (Figure  7-1).  Sickle  mice  provide  a  platform  for  preclinical  testing  of  pharmacologic  agents  for  pain  and  other  comorbidities  of  SCD.  Insights  gained  from  mouse  models  into  vascular  complications  of  SCD,  including  retinopathy,  nephropathy,  pulmonary  hypertension,  priapism,  and  leg  ulcers,  are  discussed.  Limitations  of  mouse  models  are  described,  and  future  directions  are  presented.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - hemonc.mhmedical.com/content.aspx?aid=1179338468
ER  -