TY - CHAP M1 - Book, Section TI - Hydroxyurea and Sickle Cell Disease A1 - Wang, Winfred C. A1 - Ware, Russell E. A2 - Gladwin, Mark T. A2 - Kato, Gregory J. A2 - Novelli, Enrico M. Y1 - 2021 N1 - T2 - Sickle Cell Disease AB - Landmark natural history studies, including the Cooperative Study of Sickle Cell Disease1 and the Jamaican Cohort Study,2 generated the seminal observations that fetal hemoglobin (HbF) is a critically important laboratory parameter for individuals with sickle cell anemia (SCA). Higher HbF levels are associated with better clinical outcomes including reduced mortality,3-5 and if present at sufficient levels with pancellular distribution, higher HbF levels can lead to a benign condition.6 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/02 UR - hemonc.mhmedical.com/content.aspx?aid=1179345686 ER -