TY - CHAP M1 - Book, Section TI - Bone and Extended Pelvic Resections A1 - Suidan, Rudy S. A1 - McKeown, David G. A1 - Boland, Patrick J. A2 - Bristow, Robert E. A2 - Chi, Dennis S. Y1 - 2015 N1 - T2 - Radical and Reconstructive Gynecologic Cancer Surgery AB - Most recurrent and locally advanced gynecologic malignancies carry a poor prognosis. Advances in multimodality management have improved local control and overall survival (OS).1-3 Historically, tumors invading the pelvic sidewall or involving the major vessels or nerves were considered inoperable. Early reports of central pelvic exenteration were discouraging and associated with high perioperative mortality (28%) and major complications (100%).4 Advances in several medical disciplines have resulted in greatly improved outcome and reduced morbidity and mortality in the management of these complex tumors. Increasingly effective chemotherapy and refinement in methods of radiation administration have rendered these large tumors, most of which had previous radiation therapy, amenable to wide surgical resection. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - hemonc.mhmedical.com/content.aspx?aid=1179985749 ER -