TY - CHAP M1 - Book, Section TI - Examination of Blood and Marrow Cells A1 - V.B. Reddy, Vishnu A1 - Morlote, Diana A2 - Kaushansky, Kenneth A2 - Prchal, Josef T. A2 - Burns, Linda J. A2 - Lichtman, Marshall A. A2 - Levi, Marcel A2 - Linch, David C. Y1 - 2021 N1 - T2 - Williams Hematology, 10e AB - SUMMARYExamination of the blood and marrow are mainstays of hematologic diagnosis. The decision to perform a marrow examination, and the types of special studies required, should follow from a careful analysis of blood cells and the history and physical examination of the patient. Currently available automated blood cell analyzers provide an increasing array of novel quantitative parameters and flag abnormal samples that need manual microscopic review. The marrow should be examined when the clinical history, blood cell counts, blood film, or laboratory test results suggest the possibility of a primary or secondary hematologic disorder for which morphologic analysis or special studies of the marrow would aid in the diagnosis. In addition to determining the cellularity and morphology of precursor cells, or infiltration by nonhematopoietic cells, the marrow aspirate and biopsy provide cells for immunophenotyping by flow cytometry or immunostains, cytogenetic and molecular studies, culture of infectious organisms, and storage for further analysis. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1180475824 ER -