TY - CHAP M1 - Book, Section TI - Vaccine Therapy A1 - Alatrash, Gheath A1 - Molldrem, Jeffrey J. A2 - Kaushansky, Kenneth A2 - Prchal, Josef T. A2 - Burns, Linda J. A2 - Lichtman, Marshall A. A2 - Levi, Marcel A2 - Linch, David C. Y1 - 2021 N1 - T2 - Williams Hematology, 10e AB - SUMMARYVaccines are biologic substances that are designed to stimulate the host immune system to elicit a neutralizing response against clinically relevant targets, including pathogens and tumors. Active immunotherapy with vaccines has been extremely effective as prevention against infectious pathogens. However, effective vaccine therapy of chronic infectious diseases or cancer, in the therapeutic setting, remains a promising but largely unrealized goal. Hematologic malignancies are an excellent model system for vaccine therapies, in part because of accessibility to the hematopoietic and lymphatic tissue, tumor susceptibility to immune effector mechanisms, and availability of tumor cells for mechanistic studies. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1180478048 ER -