TY - CHAP M1 - Book, Section TI - Inflammatory and Malignant Histiocytosis A1 - Lichtman, Marshall A. A1 - Kaushansky, Kenneth A1 - Prchal, Josef T. A1 - Levi, Marcel M. A1 - Burns, Linda J. A1 - Linch, David C. Y1 - 2022 N1 - T2 - Williams Manual of Hematology, 10e AB - Histiocyte is an archaic term for macrophages. The histiocytoses include diseases arising from all cells of the mononuclear phagocytic system, with diseases characterized by presumed lineage and biology into dendritic cell (DC) disorders, macrophage-related disorders, and malignant histiocytic disorders (Table 36–1).Historically, the histiocytic disorders have been characterized by the phenotype of disease-specific histiocytes (Table 36–2).Now, recurrent mitogen-activated protein kinase (MAPK) pathway mutations in clonal myeloid cells in Langerhans cell histiocytosis (LCH), Erdheim-Chester disease (ECD), juvenile xanthogranuloma (JXG), Rosai-Dorfman disease (RDD), and malignant histiocytic diseases clearly separate these neoplastic diseases of inflammatory cells from hemophagocytic lymphohistiocytosis (HLH), characterized by polyclonal reactive macrophages. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1189334109 ER -