TY - CHAP M1 - Book, Section TI - Hodgkin Lymphoma A1 - Lichtman, Marshall A. A1 - Kaushansky, Kenneth A1 - Prchal, Josef T. A1 - Levi, Marcel M. A1 - Burns, Linda J. A1 - Linch, David C. Y1 - 2022 N1 - T2 - Williams Manual of Hematology, 10e AB - Hodgkin lymphoma (HL) is a lymphoid neoplasm consisting of two distinct entities: classic Hodgkin lymphoma (cHL), accounting for 95% of cases, and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), accounting for about 5% of cases.Both types of HL are derived from germinal center B cells.cHL is defined by the presence of the Reed-Sternberg (RS) cells or its mononuclear variant Hodgkin cells with a characteristic immunophenotype and appropriate cellular background (Figures 60–1 and 60–2).The neoplastic cells account for only 1% to 5% of cells in an affected node or tissue.HL cells secrete cytokines and chemokines, which attract multiple reactive cell types, with T cells predominating. The survival of HL cells is dependent on these cells in the microenvironment.cHL consists of four histologic subtypes that are distinguished based on microscopic appearance and relative proportions of RS cells, lymphocytes, and fibrosis:— Nodular sclerosis (~60%–65% of cases) predominates in young adults. The RS cells appear as lacunar cells.— Mixed cellularity (~25%–35% of cases) predominates in older adults.— Lymphocyte-rich (~5% of cases) is most frequent in males.— Lymphocyte-depleted is very rare.The malignant cells in NLPHL are called lymphocytic/histiocytic cells or “popcorn” cells and are embedded in B-cell–rich nodules.The distinguishing pathologic features between cHL and NLPHL are shown in Table 60–1. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/14 UR - hemonc.mhmedical.com/content.aspx?aid=1189335445 ER -