TY - CHAP M1 - Book, Section TI - Mantle Cell Lymphoma A1 - Lichtman, Marshall A. A1 - Kaushansky, Kenneth A1 - Prchal, Josef T. A1 - Levi, Marcel M. A1 - Burns, Linda J. A1 - Linch, David C. Y1 - 2022 N1 - T2 - Williams Manual of Hematology, 10e AB - Mantle cell lymphoma (MCL), in its classic form, is made up of a diffuse infiltrate of small- to intermediate-size cells with irregular cleaved nuclei, dense chromatin, and indistinct nucleoli.MCL cells display an immunophenotype similar to lymphocytes in the mantle zone of normal germinal follicles: surface immunoglobulin (sIg) M+, sIgD+, CD5+, CD20+, CD10–, CD43+, BCL2+. In contrast to chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), MCL cells typically do not express CD23. MCL cells do not express the germinal center markers CD10 and BCL6, which are present in follicular lymphoma.The hallmark of MCL, present in most patients, is cyclin D1 overexpression and a t(11;14)(q13;q32).A number of variants exist, including a leukemic nonnodal variant associated with absent SOX11 expression, a blastoid/blastic variant, and a pleomorphic variant. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1189335578 ER -