TY - CHAP M1 - Book, Section TI - Myeloma A1 - Lichtman, Marshall A. A1 - Kaushansky, Kenneth A1 - Prchal, Josef T. A1 - Levi, Marcel M. A1 - Burns, Linda J. A1 - Linch, David C. Y1 - 2022 N1 - T2 - Williams Manual of Hematology, 10e AB - Myeloma is a malignancy of terminally differentiated B cells (plasma cells) that produces a complete monoclonal immunoglobulin (Ig) protein or a free light chain (FLC).Clinical and laboratory manifestations are heterogeneous but typically include:— A monoclonal Ig in plasma and/or monoclonal light chains in plasma and urine. In rare cases, the cells do not secrete a monoclonal protein in the plasma.— Decreased polyclonal Ig secretion by residual normal plasma cells, which predisposes to infections.— Hypercalcemia as a result of osteolysis.— Renal dysfunction as a result of light chain casts or hypercalcemia.— Myeloma cell proliferation in marrow leading to impaired hematopoiesis.— Osteolytic bone disease. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1189335812 ER -