TY - CHAP M1 - Book, Section TI - Dendritic Cells and Adaptive Immunity A1 - Dhodapkar, Madhav A1 - Mackall, Crystal L. A1 - Steinman, Ralph M. A2 - Kaushansky, Kenneth A2 - Lichtman, Marshall A. A2 - Prchal, Josef T. A2 - Levi, Marcel M. A2 - Press, Oliver W. A2 - Burns, Linda J. A2 - Caligiuri, Michael Y1 - 2015 N1 - T2 - Williams Hematology, 9e AB - SUMMARYDendritic cells are a multifunctional group of cells that serve as sentinels of the immune system and thus regulate many immune functions.* Dendritic cells play a central role in initiating adaptive immune responses to pathogens and initiating antitumor immune responses. Dendritic cell receptors sense environmental stimuli and can respond rapidly to both foreign pathogens and danger signals derived from tissue damage or immune complexes. Through their capacity to present antigen to T cells in immune-activating or immune-dampening contexts, dendritic cells can both induce T-cell proliferation (activation) or lack of activation (tolerance). In this way, dendritic cells help regulate immune responses mediated by T cells and B cells of the adaptive immune system. This chapter describes the varied types and functions of this important class of cells. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1121090096 ER -