TY  - CHAP
M1  - Book, Section
TI  - Production, Distribution, and Activation of Monocytes and Macrophages
A1  - Douglas, Steven D.
A1  - Douglas, Anne G.
A2  - Kaushansky, Kenneth
A2  - Lichtman, Marshall A.
A2  - Prchal, Josef T.
A2  - Levi, Marcel M.
A2  - Press, Oliver W.
A2  - Burns, Linda J.
A2  - Caligiuri, Michael
PY  - 2015
T2  - Williams Hematology, 9e
AB  - SUMMARYMonocytes  and  macrophages  play  an  important  role  in  human  biology,  both  as  a  component  of  the  hematopoietic  system  and  within  the  stroma  and  tissue  microenvironment  where  they  contribute  trophic  and  clearance  functions.  They  constitute  a  widely  dispersed  cellular  system  throughout  the  body,  interacting  with  host  cells  and  foreign  invaders  through  their  versatile  biosynthetic  and  secretory  responses,  to  maintain  physiologic  homeostasis.  They  are  specialized  migratory  or  sessile  phagocytes,  present  within  the  circulation  and  extravascular  tissue  compartment,  contributing  to  diverse  pathologic  processes  directly  and  through  their  production  of  bioactive  products.  Because  of  their  extensive  heterogeneity  and  plasticity,  the  centrality  of  monocytes  and  their  progeny  has  not  always  been  recognized  by  hematologists.  The  origin,  life  span,  and  functions  of  the  monocyte  are  the  focus  of  this  chapter,  including  their  relevance  to  health  and  disease  in  humans,  based  on  current  understanding  of  their  properties.  The  relationship  of  monocytes  and  macrophages  to  dendritic  cells,  and  monocyte-derived  cells  with  a  specialized  immunologic  role  in  T-lymphocyte  activation,  are  described.  Together,  macrophages  and  dendritic  cells  are  major  antigen-presenting  cells,  contributing  to  host  defense,  innate  and  acquired  immunity,  and  inflammation,  as  well  as  noninfectious  disease  processes,  both  within  and  outside  the  lymphohematopoietic  organs.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - hemonc.mhmedical.com/content.aspx?aid=1121096382
ER  -