TY - CHAP M1 - Book, Section TI - Vaccine Therapy A1 - Rezvani, Katayoun A1 - Molldrem, Jeffrey J. A2 - Kaushansky, Kenneth A2 - Lichtman, Marshall A. A2 - Prchal, Josef T. A2 - Levi, Marcel M. A2 - Press, Oliver W. A2 - Burns, Linda J. A2 - Caligiuri, Michael PY - 2015 T2 - Williams Hematology, 9e AB - SUMMARYVaccines are biologic substances that are designed to stimulate the host immune system to elicit a neutralizing response against clinically relevant targets, including pathogens and tumors*. Active immunotherapy with vaccines has been extremely effective as prevention against infectious pathogens. However, effective vaccine therapy of chronic infectious diseases or cancer, in the therapeutic setting, remains a promising but largely unrealized goal. Hematologic malignancies are an excellent model system for vaccine therapies, in part because of accessibility to the hematopoietic and lymphatic space and susceptibility to immune effector mechanisms and availability of tumor cells for mechanistic studies. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - hemonc.mhmedical.com/content.aspx?aid=1121090954 ER -