TY - CHAP M1 - Book, Section TI - Vascular Function in Hemostasis A1 - Hajjar, Katherine A. A1 - Marcus, Aaron J. A1 - Muller, William A2 - Kaushansky, Kenneth A2 - Lichtman, Marshall A. A2 - Prchal, Josef T. A2 - Levi, Marcel M. A2 - Press, Oliver W. A2 - Burns, Linda J. A2 - Caligiuri, Michael PY - 2015 T2 - Williams Hematology, 9e AB - SUMMARYBlood vessels, especially their endothelial lining, play a critical role in the maintenance of vascular fluidity, arrest of hemorrhage (hemostasis), prevention of occlusive vascular phenomena (thrombosis), and regulation of inflammatory cell processes.* The endothelium extends to all recesses of the body and maintains an intimate association with flowing blood and blood cells. However, endothelial cell morphologies, gene-expression profiles, and functions vary among different vascular beds. For example, in straight arterial segments, but not at branch points or curvatures of the arteries or veins, endothelial cells align themselves in parallel to the direction of blood flow. Similarly, endothelial cells in post capillary venules are primarily responsible for mediating adhesion and transmigration of leukocytes, whereas arteriolar endothelium is important for regulation of vasomotor tone. Proteomic studies have revealed that endothelial cells have the unique capacity to express and elaborate thromboregulatory molecules, which can be classified according to their chronologic appearance following vascular injury. Early thromboregulators appear prior to thrombin formation and late thromboregulators arrive after thrombin has formed. This chapter reviews some of the mechanisms by which the vascular wall regulates hemostasis, and discuss their implications for vascular health and disease (Table 115–1). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - hemonc.mhmedical.com/content.aspx?aid=1121102831 ER -