TY - CHAP M1 - Book, Section TI - Red Cell Alterations in Non-Clonal Hematological Disorders A1 - MA, Lichtman A1 - MS, Shafer A1 - RE, Felgar A1 - N, Wang PY - 2017 T2 - Lichtman's Atlas of Hematology 2016 AB - Graphic Jump LocationView Full Size||Download Slide (.ppt)I.C.001Abetalipoproteinemia. Blood film. Patients with this inherited absence of products of the apolipoprotein B gene characteristically have over 50% acanthocytes, red cells with irregular, sharp projections, in the blood. The red cell membrane abnormality is thought to reflect an excess of sphingomyelin in the outer leaflet of the membrane lipid bilayer, leading to excess surface area and sharp, irregular, spike like folds in the red cell surface. Erythroblasts do not display the abnormality and circulating cells develop it as they age in the circulation. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/02 UR - hemonc.mhmedical.com/content.aspx?aid=1138037119 ER -