TY - CHAP M1 - Book, Section TI - Anemia of Chronic Renal Disease A1 - Lichtman, Marshall A. A1 - Kaushansky, Kenneth A1 - Kipps, Thomas J. A1 - Prchal, Josef T. A1 - Levi, Marcel M. PY - 2011 T2 - Williams Manual of Hematology, 8e AB - Reduced production of erythropoietin (EPO) is the most significant factor in the development of anemia in renal insufficiency.A modest reduction in red cell life span occurs in uremia, probably as a result of metabolic impairment of red cells.Iron deficiency occurs from blood loss in dialysis tubing, laboratory testing, or external bleeding, sometimes as a result of uremia-induced platelet dysfunction. Further, increased hepcidin blocks iron absorption in the gut and iron release from macrophage stores (ameliorated by EPO therapy).The plasma volume varies widely in renal failure, with consequent variations in the hemoglobin concentration. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1126651027 ER -