TY - CHAP M1 - Book, Section TI - Follicular Lymphomas A1 - Lichtman, Marshall A. A1 - Kaushansky, Kenneth A1 - Kipps, Thomas J. A1 - Prchal, Josef T. A1 - Levi, Marcel M. PY - 2011 T2 - Williams Manual of Hematology, 8e AB - Follicular lymphoma (FL) is an indolent lymphoid neoplasm that is derived from mutated germinal center B cells and exhibits a nodular or follicular histologic pattern. It is typically composed of a mixture of small, cleaved follicle center cells referred to as centrocytes and large noncleaved follicular center cells referred to as centroblasts. The disease has masqueraded under multiple previous monikers, including "nodular lymphoma" in the Rappaport classification and "follicle center cell lymphoma" in the Working Formulation.FL accounts for approximately 20 to 25 percent of adult non-Hodgkin lymphomas (NHL) in the United States, with an annual incidence of approximately 14,000 new cases per year.The disease is uncommon in persons younger than age 20 years, and pediatric cases appear to represent a separate disease entity that is typically localized, lacks the translocation 14;18 and BCL-2 expression, and has a very good prognosis. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1126653732 ER -