TY - CHAP M1 - Book, Section TI - Inherited Deficiencies of Coagulation Factors II, V, VII, X, XI, and XIII and the Combined Deficiencies of Factors V and VIII and of the Vitamin K-Dependent Factors A1 - Lichtman, Marshall A. A1 - Kaushansky, Kenneth A1 - Kipps, Thomas J. A1 - Prchal, Josef T. A1 - Levi, Marcel M. PY - 2011 T2 - Williams Manual of Hematology, 8e AB - Inherited deficiencies of coagulation factors other than factor VIII (hemophilia A) and factor IX (hemophilia B) are rare bleeding disorders that occur in most populations.Patients are usually homozygotes or compound heterozygotes.Factor XI and factor VII deficiency occur relatively frequently, other deficiencies are relatively rare (Table 82–1).The severity of the bleeding disorder usually relates to the severity of the factor deficiency.All may be caused by decreased synthesis of a specific coagulation factor, by synthesis of a dysfunctional form of the coagulation factor, or both.Inherited deficiency of a coagulation factor does not protect patients from thrombosis. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/05 UR - hemonc.mhmedical.com/content.aspx?aid=1126654727 ER -