TY - CHAP M1 - Book, Section TI - Hemostatic Dysfunction Related to Liver Diseases A1 - Lichtman, Marshall A. A1 - Kaushansky, Kenneth A1 - Kipps, Thomas J. A1 - Prchal, Josef T. A1 - Levi, Marcel M. PY - 2011 T2 - Williams Manual of Hematology, 8e AB - Loss of hepatic parenchymal cells leads to decreased plasma levels of all plasma coagulation factors except factor VIII and von Willebrand factor.Thrombocytopenia occurs frequently and is usually a result of splenic sequestration (see Chap. 74), but may also be caused by an autoimmune mechanism, disseminated intravascular coagulation (DIC), folic acid deficiency, and decreased platelet production. In some patients, thrombocytopenia due to thrombopoietin (TPO) deficiency and platelet dysfunction contribute to the hemostatic abnormalities.Enhanced fibrinolysis is common, and appears to be caused by complex pathogenetic mechanisms, including release and impaired clearance of plasminogen activators.Dysfibrinogenemia is relatively frequently found in patients with chronic liver disease.Patients with chronic liver disease may develop DIC. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/12 UR - hemonc.mhmedical.com/content.aspx?aid=1126654750 ER -