TY - CHAP M1 - Book, Section TI - Cancer Genomics A1 - Goldstein, Jennifer B. A1 - Zhang, Zhijing A1 - Futreal, Andy A2 - Kantarjian, Hagop M. A2 - Wolff, Robert A. PY - 2016 T2 - The MD Anderson Manual of Medical Oncology, 3e AB - Over the past 50 years, multiple discoveries have had an impact on our understanding of key genomic events that influence the development of malignant growth. After many large-scale sequencing projects of cancer genomes, we now understand that many genetic alterations in specific cancer genes are responsible for the development and progression of the disease. These alterations may occur at the level of the patient’s germline, predisposing to inherited forms of cancer that may develop in many tissues throughout the body. Genetic alterations may also be somatic, or newly acquired changes within the genes of an individual cell or group of cells over time and due to environmental stresses. Somatic alterations may come in many forms, including single-base substitutions; insertions or deletions of DNA fragments; rearrangements and rejoining of DNA from alternative locations in the genome; and copy number increases and reductions. Should these alterations effect key cancer genes, malignancy may develop. SN - PB - McGraw-Hill Medical CY - New York, NY Y2 - 2024/03/29 UR - hemonc.mhmedical.com/content.aspx?aid=1126745727 ER -