TY - CHAP M1 - Book, Section TI - Oncogenes and Tumor-Suppressor Genes A1 - Dutt, Previn A1 - Stambolic, Vuk A2 - Tannock, Ian F. A2 - Hill, Richard P. A2 - Bristow, Robert G. A2 - Harrington, Lea PY - 2016 T2 - The Basic Science of Oncology, 5e AB - Cancer is fundamentally a genetic disease. It results in expansion of a cellular population that invades and destroys surrounding organs and tissues and gains the ability to spread throughout the body. The second half of the 20th century inaugurated a steady stream of breakthroughs in the field of cancer research, largely spurred by an explosion of technologies enabling the analysis of tumors at a molecular level. Recent dramatic advancements in low-cost high-throughput sequencing of cancer genomes and the development of high-resolution genome-wide profiling of the changes in gene copy number and structure are enabling detailed mapping of the genetic events associated with cellular transformation from nonmalignant to malignant cell. SN - PB - McGraw-Hill Education Medical CY - New York, NY Y2 - 2024/10/05 UR - hemonc.mhmedical.com/content.aspx?aid=1127471920 ER -