TY - CHAP M1 - Book, Section TI - Follicular Lymphoma A1 - Sievers, Amy A1 - LaCasce, Ann A2 - Chabner, Bruce A. A2 - Longo, Dan L. PY - 2016 T2 - Harrison's Manual of Oncology, 2e AB - Follicular lymphoma (FL) represents 20%–30% of all non-Hodgkin lymphomas (NHL) and is the second most common NHL in Western populations after diffuse large B-cell lymphoma (DLBCL) (1). FL comprises about 80% of the indolent NHLs. The term follicular is derived from the tendency of the neoplastic cells to form microscopic nodules. The cell of origin is the follicular center B cell. Eighty-five to 90% of all cases harbor the characteristic cytogenetic translocation t(14;18), resulting in the placement of the anti-apoptotic bcl-2 gene under the control of the immunoglobulin (Ig) heavy-chain promoter on chromosome 14. Follicular lymphoma is considered incurable without stem-cell transplantation, with the exception of localized disease that may be cured with radiotherapy in a subset of patients. Treatment is therefore based on disease control rather than cure, and eventual relapse after treatment is the usual natural history of FL (2). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1127648216 ER -