TY - CHAP M1 - Book, Section TI - Anal Cancer A1 - Wo, Jennifer A2 - Chabner, Bruce A. A2 - Longo, Dan L. PY - 2016 T2 - Harrison's Manual of Oncology, 2e AB - Anal cancer is responsible for approximately 2.1% of digestive system malignancies with 6230 new cases estimated in the United States in 2012 (1). Anal cancer was once believed to be caused by chronic inflammation of the anal canal and treated with abdominoperineal resection (APR). Research has now shown that the development of anal cancer is associated with human papillomavirus (HPV) infection and has a pathophysiology similar to that of cervical cancer. Concurrent chemotherapy and external beam radiation therapy (EBRT) regimens have essentially replaced APR as primary treatment and have allowed for a great majority of patients to be cured with preservation of the anal sphincter. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1127649103 ER -