TY - CHAP M1 - Book, Section TI - CARCINOMA OF UNKNOWN PRIMARY A1 - Varadhachary, Gauri R. A1 - Abbruzzese, James L. A2 - Longo, Dan L. PY - 2013 T2 - Harrison's Hematology and Oncology, 2e AB - Carcinoma of unknown primary (CUP) is a biopsy-proven (mainly epithelial) malignancy for which the anatomic site of origin remains unidentified after an intensive search. CUP is one of the 10 most frequently diagnosed cancers worldwide, accounting for approximately 3–5% of all cancers. Most investigators do not include lymphomas, metastatic melanomas, and metastatic sarcomas that present without a known primary tumor as CUP because these cancers have specific stage- and histology-based treatments that guide management. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/18 UR - hemonc.mhmedical.com/content.aspx?aid=1128357872 ER -