TY - CHAP M1 - Book, Section TI - Polycythemia Vera A1 - Lichtman, Marshall A. A1 - Kaushansky, Kenneth A1 - Prchal, Josef T. A1 - Levi, Marcel M. A1 - Burns, Linda J. A1 - Armitage, James O. PY - 2017 T2 - Williams Manual of Hematology, 9e AB - Polycythemia vera (PV) is a clonal disorder arising from somatic mutations of a multipotential hematopoietic cell, in which blood cell production, notably erythropoiesis, is increased independent of cytokine regulation. This results in exaggerated proliferation and accumulation of erythrocytic, and often also granulocytic, and megakaryocytic cells. PV is one of the myeloproliferative neoplasms (MPN), along with essential thrombocythemia (ET), primary myelofibrosis (MF), and chronic myelogenous leukemia (CML).Three myeloproliferative neoplasms (PV, ET, MF) share a common molecular abnormality/marker, the JAK2 kinase V617F mutation. CML stands alone; it has a different molecular marker (bcr/abl, due to a reciprocal translocation between chromosome 9 and chromosome 22, t(9;22)(q34;q11)). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - hemonc.mhmedical.com/content.aspx?aid=1133363973 ER -