TY  - CHAP
M1  - Book, Section
TI  - Hodgkin Lymphoma
A1  - Lichtman, Marshall A.
A1  - Kaushansky, Kenneth
A1  - Prchal, Josef T.
A1  - Levi, Marcel M.
A1  - Burns, Linda J.
A1  - Armitage, James O.
PY  - 2017
T2  - Williams Manual of Hematology, 9e
AB  - The  neoplasm  of  lymphoid  tissue  in  most  cases  is  derived  from  germinal  center  B  cells,  defined  by  the  presence  of  the  Reed-Sternberg  cells  or  its  mononuclear  variant  Hodgkin  cells  with  a  characteristic  immunophenotype  and  appropriate  cellular  background.The  Reed-Sternberg  and  Hodgkin  cell,  the  neoplastic  cells  defining  Hodgkin  disease,  are  considered  of  B-cell  origin  based  on  their  clonal  immunoglobulin  gene  rearrangements.Classic  Hodgkin  disease  accounts  for  95%  of  cases  and  contains  four  histologic  subtypes  that  are  distinguished  on  the  basis  of  microscopic  appearance  and  relative  proportions  of  Reed-Sternberg  cells,  lymphocytes,  and  fibrosis:  nodular  sclerosis,  mixed  cellularity,  lymphocyte-depleted,  or  lymphocyte-rich  Hodgkin  disease.  A  fifth  subtype,  nodular  lymphocyte  predominance  has  been  added  to  the  four  classic  histologic  types  (Table  59–1).  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/17
UR  - hemonc.mhmedical.com/content.aspx?aid=1133364979
ER  -