TY - CHAP M1 - Book, Section TI - Myeloma A1 - Lichtman, Marshall A. A1 - Kaushansky, Kenneth A1 - Prchal, Josef T. A1 - Levi, Marcel M. A1 - Burns, Linda J. A1 - Armitage, James O. PY - 2017 T2 - Williams Manual of Hematology, 9e AB - Myeloma is a malignancy of terminally differentiated B cells (plasma cells) that produces a complete and/or partial (light chain) monoclonal immunoglobulin protein.Clinical and laboratory manifestations are heterogeneous but typically include:— A monoclonal immunoglobulin in plasma and/or monoclonal light chains in plasma and urine. In rare cases, the cells do not secrete a monoclonal protein in the plasma— Decreased polyclonal immunoglobulin secretion by residual normal plasma cells, which predispose to infections— Myeloma cell proliferation in marrow leading to impaired hematopoiesis— Osteolytic bone disease— Often hypercalcemia as a result of osteolysis— Renal dysfunction as a result of light chain casts or hypercalcemia SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1133365364 ER -