TY - CHAP M1 - Book, Section TI - High-Risk Breast Pathology A1 - Degnim, Amy C. A2 - Morita, Shane Y. A2 - Balch, Charles M. A2 - Klimberg, V. Suzanne A2 - Pawlik, Timothy M. A2 - Posner, Mitchell C. A2 - Tanabe, Kenneth K. PY - 2018 T2 - Textbook of Complex General Surgical Oncology AB - The phrase “high-risk breast pathology” has two meanings. Classically, it refers to specific histologic findings in breast biopsy tissue that portend an increased risk of breast cancer for a woman in the years after the breast biopsy. With the shift in recent years from surgical excision of breast lesions to the routine use of percutaneous biopsy for diagnosis, high-risk breast pathology has also taken on a second meaning—breast lesions identified at percutaneous biopsy that may be malignant but are not adequately diagnosed with the percutaneous approach and therefore require surgical excision for definitive exclusion of malignancy. Thus, they are “high-risk” because they indicate a substantial risk that cancer is currently present in the breast at the needle biopsy site. Classic high-risk lesions with proven increase in long-term breast cancer risk include lobular carcinoma in situ (LCIS), atypical lobular hyperplasia (ALH), and atypical ductal hyperplasia (ADH). Other high-risk breast pathology lesions with less long-term risk but with concern for upgrade after needle biopsy include flat epithelial atypia, radial scar, and papillary lesions. This chapter will address both aspects of increased risk for these lesions—long-term increase in breast cancer risk as well as the risk of “upgrade” to cancer with surgical excision of the percutaneous biopsy site. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1145760042 ER -