TY - CHAP M1 - Book, Section TI - Gastrointestinal Stromal Tumors A1 - Fairweather, Mark A1 - Raut, Chandrajit P. A2 - Morita, Shane Y. A2 - Balch, Charles M. A2 - Klimberg, V. Suzanne A2 - Pawlik, Timothy M. A2 - Posner, Mitchell C. A2 - Tanabe, Kenneth K. PY - 2018 T2 - Textbook of Complex General Surgical Oncology AB - Gastrointestinal stromal tumor (GIST) is a rare malignancy of mesenchymal origin. The true incidence of GIST has historically been underestimated as these tumors were commonly misclassified as leiomyomas, leiomyosarcomas, and leiomyoblastomas.1 The term gastric stromal tumor was first proposed in 1983 to describe gastric wall tumors that lacked the ultrastructural features of smooth muscle cells and the immunohistochemical characteristics of Schwann cells.2 Mazur and Clark2 examined 28 gastric wall tumors that were originally classified by light microscopy as leiomyomas or leiomyosarcomas and, using electron microscopy, determined that some of these tumors lacked features expected in cells derived from smooth muscle. Additionally, using immunohistochemistry to identify the neuroectoderm marker S-100, they found that the majority of tumors failed to show evidence of a nerve sheath origin. They postulated that this subset of tumors that did not appear from a smooth muscle origin or peripheral nerve origin may arise from the myenteric nervous system. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1145763228 ER -