TY - CHAP M1 - Book, Section TI - General Principles of Antimicrobial Therapy A1 - Gumbo, Tawanda A2 - Brunton, Laurence L. A2 - Hilal-Dandan, Randa A2 - Knollmann, Björn C. PY - 2017 T2 - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e AB - AbbreviationsABC: ATP binding cassetteAUC: area under the Cp-time curveCCR5: chemokine receptor type 5CD4: T-helper cellsCFU: colony-forming unitCMV: cytomegalovirusCNS: central nervous systemCp: plasma concentrationCPmax: peak concentrationCSF: cerebrospinal fluidDHFR: dihydrofolate reductaseDHPS: dihydropteroate synthaseE: effectEC: effective concentrationELF: epithelial lining fluidEmax: maximal effectH: the slope of the curve or Hill factorHIV: human immunodeficiency virusIC: inhibitory concentrationMALDI-TOF MS: matrix-assisted laser desorption/ionization time-of-flight mass spectrometrymdr1: multidrug resistance geneMEC: minimum effective concentrationMIC: minimum inhibitory concentrationPAE: post antibiotic effectPCR: polymerase chain reactionPK/PD: pharmacokinetics-pharmacodynamicsrpoB: RNA polymerase SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1162543663 ER -