TY - CHAP M1 - Book, Section TI - Disseminated Intravascular Coagulation A1 - Levi, Marcel A1 - Seligsohn, Uri A2 - Kaushansky, Kenneth A2 - Levi, Marcel PY - 2017 T2 - Williams Hematology Hemostasis and Thrombosis AB - SUMMARYWhen procoagulants are produced or introduced into the blood and overcome the anticoagulant mechanisms of coagulation, intravascular thrombin is generated systemically, which can lead to disseminated intravascular coagulation (DIC). The clinical manifestations of intravascular coagulation include (1) multiorgan dysfunction caused by microthrombi; (2) bleeding caused by consumption of platelets, fibrinogen, and other coagulation factors; and (3) secondary fibrinolysis. Exposure of blood to tissue factor is the most common trigger. This event can occur when mononuclear cells and endothelial cells are induced to generate and express tissue factor during the systemic inflammatory response syndrome (e.g., Gram-negative and Gram-positive infections, fungemia, burns, severe trauma), or when contact is established between blood and tissue factor constitutively present on membranes of cells foreign to blood (e.g., malignant, placental, brain, adventitial cells, or traumatized tissues). Laboratory features include thrombocytopenia, reduced levels of fibrinogen and other coagulation factors (leading to prolonged partial thromboplastin, prothrombin, and thrombin times), and elevated levels of D-dimer and fibrin(ogen) degradation products. Several underlying disorders affect these hemostatic parameters and can lead to a false-positive diagnosis of DIC (e.g., liver disease–related coagulation abnormalities and thrombocytopenia) or to a false-negative diagnosis (e.g., pregnancy-related high fibrinogen levels). Reexamining these variables every 6 to 8 hours may permit a specific diagnosis. Early detection, vigorous treatment of the underlying disorder, and support of vital functions are essential for survival of affected patients. Blood component therapy is effective in patients who bleed excessively, whereas heparin administration is indicated in a limited number of circumstances. Intravascular coagulation and the underlying disorders causing it contribute to a high rate of mortality. The severity of the organ dysfunction and extent of hemostatic failure, as well as increasing patient age, have been associated with a grave prognosis. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/12/04 UR - hemonc.mhmedical.com/content.aspx?aid=1148373305 ER -