TY  - CHAP
M1  - Book, Section
TI  - Unknown Primary: Work-up and Treatment
A1  - O'Donnell, Dearbhaile
A1  - Leahy, Michael
A1  - Marples, Maria
A1  - Protheroe, Andrew
A1  - Selby, Peter
PY  - 2018
T2  - Problem Solving in Oncology
AB  - A  65-year-old  smoker  presents  with  pain  in  the  right  hip  and  a  plain  radiograph  shows  a  lytic  lesion  with  a  pathological  fracture  in  the  neck  of  the  right  femur.  He  has  been  reasonably  well  prior  to  this  and  a  good-quality  chest  radiograph  is  reported  as  showing  normal  findings.What  investigations  are  indicated?  How  extensive  should  be  the  search  for  the  primary?What  is  the  value  of  serum  tumour  markers  in  the  diagnosis  of  an  unknown  primary?What  about  emerging  technologies  such  as  gene  profiling?What  are  the  basic  principles  to  guide  management  -  looking  for  the  treatable?Assuming  the  final  diagnosis  is  carcinoma  of  unknown  primary,  what  are  the  results  from  treatment  with  chemotherapy?What  are  the  options  and  the  optimal  local  treatment  for  the  fracture?  
SN  - 
PB  - Clinical Publishing Oxford
CY  - New York, NY
Y2  - 2021/03/06
UR  - hemonc.mhmedical.com/content.aspx?aid=1152354761
ER  -