TY - CHAP M1 - Book, Section TI - Thalassemia A1 - Bunn, H. Franklin A1 - Sankaran, Vijay G. A2 - Aster, Jon C. A2 - Bunn, H. Franklin PY - 2016 T2 - Pathophysiology of Blood Disorders, 2e AB - LEARNING OBJECTIVESAfter studying this chapter, you should be able to:Outline the changes in globin gene expression that occur during fetal development.Explain the molecular genetics and inheritance of alpha (α)- and beta (β)-thalassemias.Grasp the cellular pathogenesis of α- and β-thalassemias.Describe the clinical and laboratory features of β-thalassemia minor (trait) and β-thalassemia major and the different types of α-thalassemia.Understand the pathophysiologic principles underlying treatment of β-thalassemia major. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1175524796 ER -