TY - CHAP M1 - Book, Section TI - Methods of Molecular Analysis A1 - Boutros, Paul C. A1 - Harrington, Lea A1 - Kislinger, Thomas A2 - Harrington, Lea A. A2 - Tannock, Ian F. A2 - Hill, Richard P. A2 - Cescon, David W. PY - 2021 T2 - The Basic Science of Oncology, 6e AB - Advances in understanding the biology of cancer have transformed the field of oncology. Although genetic analysis was limited previously to gross chromosomal abnormalities in karyotypes, DNA and RNA in cells can now be analyzed at the individual base-pair level, and there is increasing knowledge about the structure and interactions of proteins. This intricate knowledge of the molecular properties of cancer increases the possibility that personalized treatment for individual cancers might be achieved. To appreciate the relevance and nature of these technological advances, as well as their implications for function, an understanding of the modern tools of molecular biology is essential. This chapter reviews the cytogenetic, nucleic, proteomic, and bioinformatics methods used to study the molecular basis of cancer, and highlights methods that are likely to affect its future management. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1179323269 ER -