TY - CHAP M1 - Book, Section TI - Angiogenesis A1 - Rak, Janusz A1 - Emmenegger, Urban A2 - Harrington, Lea A. A2 - Tannock, Ian F. A2 - Hill, Richard P. A2 - Cescon, David W. PY - 2021 T2 - The Basic Science of Oncology, 6e AB - An important feature of malignancies is the emergence of new and abnormal contact points between cancer cells and the host vascular system (Folkman, 2007). Prior to transformation, many epithelial tissues (eg, in the gut, skin, and exocrine glands) are anatomically separated from the vasculature by basement membranes and/or connective tissue layers. These barriers are compromised during the malignant process, resulting in abnormal interactions between vascular components (endothelial cells, blood cells, plasma, or lymph) and cancer cells at this new tumor-vascular interface (Rak, 2009). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1179324431 ER -