TY - CHAP M1 - Book, Section TI - Cancer Heterogeneity A1 - Gedye, Craig A2 - Harrington, Lea A. A2 - Tannock, Ian F. A2 - Hill, Richard P. A2 - Cescon, David W. PY - 2021 T2 - The Basic Science of Oncology, 6e AB - Every patient’s cancer is different. Cancers arising from the same organ may have different histology and metastatic potential, may be indolent or aggressive, and may have different response to therapy. Cells within a cancer are also different. Within individual tumors, some cells are genetically normal stromal cells and some are somatically-mutated malignant cells. And within the malignant cell pool, related but differently evolved malignant clones vie for survival, exploiting different epigenetic strategies, within different microenvironments within each tumor (Fig. 13–1; see Chap. 12, Sec. 12.2). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/08 UR - hemonc.mhmedical.com/content.aspx?aid=1179324803 ER -