TY  - CHAP
M1  - Book, Section
TI  - Sickle Cell Disease in Jamaica: Observations From a Small Island
A1  - Serjeant, Graham
A1  - Serjeant, Beryl
A2  - Gladwin, Mark T.
A2  - Kato, Gregory J.
A2  - Novelli, Enrico M.
PY  - 2021
T2  - Sickle Cell Disease
AB  - Jamaica  is  an  island  in  the  Caribbean  approximately  140  km  south  of  Cuba.  Maximum  dimensions  are  235  km  long  and  84  km  wide,  with  a  land  mass  of  10,911  km2  and  an  estimated  population  of  2.9  million  in  2018.  The  people  are  predominantly  of  West  African  origin,  with  smaller  groups  from  India,  China,  the  Mediterranean,  and  northern  Europe,  especially  the  United  Kingdom.  This  diversity  results  in  a  population  where  10%  have  the  sickle  cell  trait,  3.5%  have  the  HbC  trait,  and  0.9%  have  the  β  thalassemia  trait.  Although  Jamaica  is  in  many  ways  a  developing  society,  it  has  excellent  public  health  and  medical  facilities  and  is  malaria  free.  Furthermore,  some  sophistication  results  from  its  closeness  geographically  to  the  United  States  and  culturally  to  the  United  Kingdom,  which  also  means  that  these  countries  are  home  to  a  large  Jamaican  diaspora.  Within  Jamaica,  despite  a  shift  of  the  population  toward  urban  centers,  nearly  half  the  people  reside  in  rural  areas  where  they  maintain  stable  households.  This  population  structure  is  invaluable  for  long-term  follow-up  of  patients  and,  hence,  ideal  for  studies  of  the  natural  history  of  disease  generally  and  has  provided  a  unique  “island  laboratory”  for  studies  of  sickle  cell  disease.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - hemonc.mhmedical.com/content.aspx?aid=1179345808
ER  -