TY - CHAP M1 - Book, Section TI - Regenerative Medicine: Induced Pluripotent Stem Cells And Blood Cell Engineering A1 - Turhan, Ali G. A1 - Bennaceur-Griscelli, Annelise A1 - Eaves, Connie J. A2 - Kaushansky, Kenneth A2 - Prchal, Josef T. A2 - Burns, Linda J. A2 - Lichtman, Marshall A. A2 - Levi, Marcel A2 - Linch, David C. PY - 2021 T2 - Williams Hematology, 10e AB - SUMMARYThe first two decades of the 21st century have shown major breakthroughs in the development of protocols for generating human hematopoietic cells ex vivo and for engineering them genetically. These breakthroughs have come from the discovery that immortal lines of pluripotent cells, very similar to embryonic stem cells and capable of generating cells of all tissues, can be readily derived from many types of mature human cells. Also significant has been the development of strategies for targeting genetic changes in genomic DNA with unprecedented specificity and efficiency. These findings make it possible to analyze and manipulate previously inaccessible stages of human tissue development and human disease processes. These capabilities have also sparked the pursuit of new systems for testing novel treatments that were recently seen as “pipe dreams.” Together, the promise afforded these initial, but seminal, advances has changed our appreciation of the future landscape of general regenerative medicine and for hematologic diseases in particular. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - hemonc.mhmedical.com/content.aspx?aid=1180478188 ER -