TY  - CHAP
M1  - Book, Section
TI  - Clinical Cancer Genetics
A1  - Boland, C. Richard
A1  - Peltomaki, Paivi
A2  - Llor, Xavier
A2  - Hofstatter, Erin Wysong
PY  - 2022
T2  - Cancer Genetics: A Clinical Approach
AB  - Cancer  has  been  recognized  as  a  specific  pathological  entity  since  the  nineteenth  century,  and  there  have  been  multiple  proposed  mechanistic  explanations  for  this  disease  process.  Theodor  Boveri  determined  that  cancer  was  a  cellular  process  caused  by  a  scrambling  of  the  chromosomes,  and  in  1902,  he  proposed  that  physical  insults  such  as  radiation,  chemical  agents,  or  even  microbial  pathogens  might  be  responsible  for  this.  Over  the  past  120  years,  most  of  Boveri’s  proposed  triggers  have  been  linked  to  cancer.  Although  abnormalities  in  chromosomes  are  frequently  found  in  cancers,  the  degree  of  aneuploidy  is  quite  diverse  among  tumors,  and  a  few  cancers  are  nearly  diploid  (but  may  be  highly  mutated).  However,  every  cancer  has  genetic  aberrations  of  some  sort,  and  all  investigators  involved  in  cancer  research  agree  that  cancer  is  fundamentally  a  genetic  disease.  Most  cancers  are  not  a  result  of  inherited  germline  mutations  (or  epimutations),  but  all  cancers  are  driven  by  aberrant  gene  expression.  The  variety  of  ways  through  which  cancers  develop  and  the  heterogeneity  of  genetic  alterations  in  tumors  have  served  to  fascinate  and  perplex  those  who  study  the  disease.  
SN  - 
PB  - McGraw Hill
CY  - New York, NY
Y2  - 2024/04/18
UR  - hemonc.mhmedical.com/content.aspx?aid=1182364839
ER  -