TY - CHAP M1 - Book, Section TI - Genetic Predisposition to Gastric Cancer A1 - Guivatchian, Tannaz A1 - Stoffel, Elena M. A2 - Llor, Xavier A2 - Hofstatter, Erin Wysong PY - 2022 T2 - Cancer Genetics: A Clinical Approach AB - Gastric cancer is currently the fifth most common cause of cancer and the third-leading cause of cancer death worldwide, accounting for 1.3 million incident cases and 819,000 deaths annually.1 The incidence of gastric cancer varies geographically, with incidence highest in East Asia and South America and lowest in Western countries. While the incidence of gastric cancer is declining overall (possibly due to treatment of H. pylori infection), incidence of cancers arising from the gastric cardia continues to increase in developed countries (including the United States) for unknown reasons.2 There are gender differences in gastric cancer, with incidence 2- to 3-fold higher in men compared to women.2 SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/04/20 UR - hemonc.mhmedical.com/content.aspx?aid=1182366252 ER -