TY  - CHAP
M1  - Book, Section
TI  - Classification and Clinical Manifestations of Neutrophil Disorders
A1  - Lichtman, Marshall A.
A1  - Kaushansky, Kenneth
A1  - Prchal, Josef T.
A1  - Levi, Marcel M.
A1  - Burns, Linda J.
A1  - Linch, David C.
PY  - 2022
T2  - Williams Manual of Hematology, 10e
AB  - Normal  neutrophil  concentration  values  are  significantly  lower  for  certain  ethnic  groups  (eg,  African  ancestry,  Yemeni  Jewish  ancestry)  than  for  persons  of  European  ancestry.  This  difference  is  an  important  distinction  to  avoid  unnecessary  evaluations  in  these  individuals.  Men  of  African  ancestry  may  have  a  “normal”  absolute  neutrophil  count  of  1.3  to  6.6  ×  109/L.In  this  classification,  diseases  resulting  from  neutrophil  abnormalities  in  which  the  neutrophil  is  either  the  only  cell  type  affected  or  is  the  dominant  cell  type  affected  are  considered  (Table  29–1).Neutropenia  or  neutrophilia  occurs  as  part  of  disorders  that  affect  multiple  blood  cell  lineages  (eg,  aplastic  anemia  [see  Chap.  3],  myelodysplastic  syndrome  [see  Chap.  45],  acute  and  chronic  myelogenous  leukemias  [see  Chaps.  46  and  47],  chronic  myeloproliferative  diseases  [see  Chaps.  42,  43,  and  48]).A  strict  pathophysiologic  classification  of  neutrophil  disorders  has  proved  elusive  because:—  The  low  concentration  of  blood  neutrophils  in  neutropenic  states  makes  measuring  the  circulatory  kinetics  of  autologous  cells  technically  difficult.—  The  two  compartments  of  neutrophils  in  the  blood  (the  circulating  compartment  measured  by  the  absolute  neutrophil  count  and  the  marginated  neutrophil  compartment  sequestered  in  small  vessel  beds  and  not  counted  in  the  neutrophil  count),  the  random  disappearance  of  neutrophils  from  the  circulation,  the  extremely  short  circulation  time  of  neutrophils  (t1/2  =  ~6  hours),  the  absence  of  facile  techniques  to  measure  the  size  of  the  tissue  neutrophil  compartment,  and  the  disappearance  of  neutrophils  by  apoptosis  or  gastrointestinal  excretion  from  the  tissue  compartment  make  multicompartment  kinetic  analysis  difficult.Thus,  the  classification  of  neutrophil  disorders  is  partly  pathophysiologic  and  partly  descriptive  (see  Table  29–1).  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - hemonc.mhmedical.com/content.aspx?aid=1189333805
ER  -