TY  - CHAP
M1  - Book, Section
TI  - Large Granular Lymphocytic Leukemia
A1  - Lichtman, Marshall A.
A1  - Kaushansky, Kenneth
A1  - Prchal, Josef T.
A1  - Levi, Marcel M.
A1  - Burns, Linda J.
A1  - Linch, David C.
PY  - 2022
T2  - Williams Manual of Hematology, 10e
AB  - T-cell  large  granular  lymphocytic  leukemia  (T-LGLL)  results  from  an  indolent  clonal  expansion  of  large  granular  lymphocytes  (LGLs)  with  a  T-cell  (CD3+)  phenotype  and  a  clonal  T-cell  receptor  gene  rearrangement(s),  usually  α  and  β  chains.Diagnosis  of  T-LGLL  requires  an  arbitrary  level  in  the  blood  of  CD3+CD8+CD57+  cells  that  is  greater  than  0.5  ×  109/L  maintained  for  at  least  6  months.  CD5  is  dimly  expressed.Chronic  lymphoproliferative  disorders  of  natural  killer  cells  (CLPD-NK)  is  a  clonal  expansion  of  LGL  with  a  NK  cell  (CD3–)  phenotype.  It  lacks  convenient  markers  to  determine  clonality,  such  as  antigen  receptor  rearrangements.  (See  Chap.  67.)Diagnosis  of  CLPD-NK  requires  an  arbitrary  level  in  the  blood  of  CD3–CD8+CD16+  and/or  CD16+CD56+  cells  that  is  greater  than  0.75  ×  109/L  maintained  for  at  least  6  months.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2023/06/04
UR  - hemonc.mhmedical.com/content.aspx?aid=1189335371
ER  -