TY - CHAP M1 - Book, Section TI - Genomics A1 - Wartman, Lukas D. A1 - Mardis, Elaine R. A2 - Kaushansky, Kenneth A2 - Lichtman, Marshall A. A2 - Prchal, Josef T. A2 - Levi, Marcel M. A2 - Press, Oliver W. A2 - Burns, Linda J. A2 - Caligiuri, Michael PY - 2015 T2 - Williams Hematology, 9e AB - SUMMARYThe introduction of next-generation sequencing platforms, coincident with genome-scale preparatory and analytical approaches and the completion of the Human Genome Reference, has ushered in the era of genomics. This chapter introduces the fundamentals of next-generation sequencing methods, provides an overview of the basics of data analysis, and explores the myriad applications developed to exploit the scale and throughput of next-generation sequencing toward questions of biomedical importance. Specifics of cancer genomics, complex disease genomics, and how they pertain to hematologic basic science and clinical practice are discussed, along with the modern-day realities of the consenting process. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1121089282 ER -