TY - CHAP M1 - Book, Section TI - Anemia Associated with Marrow Infiltration A1 - Reddy, Vishnu VB A1 - Prchal, Josef T. A2 - Kaushansky, Kenneth A2 - Lichtman, Marshall A. A2 - Prchal, Josef T. A2 - Levi, Marcel M. A2 - Press, Oliver W. A2 - Burns, Linda J. A2 - Caligiuri, Michael PY - 2015 T2 - Williams Hematology, 9e AB - SUMMARYMyelophthisic anemia is caused by marrow infiltration, typically by metastatic cancer, and by any nonhematopoietic conditions, for example, granulomatous inflammation or fibrosis. It can present with an overt leukoerythroblastic picture or with only a few teardrop-shaped red cells on a blood film. These changes may represent an early spread of the tumor (or other nonhematopoietic tissue) to the marrow or may indicate massive replacement of the marrow space. The diagnosis can be made by standard marrow biopsy. Radioisotope scanning and magnetic resonance imaging, although not very sensitive, can be helpful in locating the biopsy site and can also help in estimating the percentage of involvement of the marrow space. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1121092966 ER -