RT Book, Section
A1 Smith, C. Wayne
A2 Kaushansky, Kenneth
A2 Lichtman, Marshall A.
A2 Prchal, Josef T.
A2 Levi, Marcel M.
A2 Press, Oliver W.
A2 Burns, Linda J.
A2 Caligiuri, Michael
SR Print(0)
ID 1121095474
T1 Structure and Composition of Neutrophils, Eosinophils, and Basophils
T2 Williams Hematology, 9e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071833004
LK hemonc.mhmedical.com/content.aspx?aid=1121095474
RD 2024/04/18
AB SUMMARYEarly  in  precursor  development  in  the  marrow,  cells  destined  to  be  leukocytes  of  the  granulocytic  series—neutrophils,  eosinophils,  and  basophils—synthesize  proteins  and  store  them  as  cytoplasmic  granules.  The  synthesis  of  primary  or  azurophilic  granules  defines  the  conversion  of  the  myeloblast,  a  virtually  agranular,  primitive  cell  that  is  the  earliest  granulocyte  precursor  identifiable  by  light  microscopy,  into  the  promyelocyte,  which  is  rich  in  azurophilic  granules.  Synthesis  and  accumulation  of  secondary  or  specific  granules  follows.  The  appearance  of  specific  granules  marks  the  progression  of  the  promyelocyte  to  neutrophilic,  eosinophilic,  or  basophilic  myelocytes.  Thereafter,  the  cell  continues  maturation  into  an  amitotic  cell  with  a  segmented  nucleus,  capable  of  chemotaxis,  phagocytosis  and  microbial  killing.  The  mature  granulocytes  also  develop  cytoplasmic  and  surface  structures  that  permit  them  to  attach  to  and  penetrate  the  wall  of  venules.  The  mature  granulocytes  enter  the  blood  from  the  marrow,  circulate  briefly,  and  move  to  the  tissues  to  carry  out  their  major  function  of  host  defense.  Blood  neutrophils  exhibit  the  capacity  for  changes  in  phenotypic  characteristics  and  life  span  depending  on  the  stimulating  milieu  of  cytokines  and  chemokines.  Gene  expression  profiling  studies  indicate  the  neutrophil  is  a  transcriptionally  active  cell,  responsive  to  environmental  stimuli,  and  capable  of  a  complex  series  of  early  and  late  changes  in  gene  expression.